I stumbled across this review article (first full reference below) earlier this week. Skin cancer is the most common form of cancer in the United States. Most skin cancers form in older people on parts of the body exposed to the sun or in people who have weakened immune systems (such as inflammatory bowel disease patients on immunosuppressive therapy). According to the National Cancer Institute (NCI), in there were more than one million new cases of nonmelanoma skin cancers (NMSC) in the United States in 2010. There were less than 1,000 NMSC deaths during the same time. NMSC includes squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Both occur more frequently on sunlight-exposed areas such as the head and neck. BCC is far more c...
Rooster Quilt
This miniature quilt is made using a feed sack which held rice. The rooster logo is framed by a black and then a red/black sash. The quilt measures 10.5 in X 12.75 in. It is machine pieced. It is machine and hand quilted. This photo shows the rooster and quilting better. The rooster is quilted with cross-hatching while the outer area is an intertwined cable. These were hand quilted. The area next to the black strip was machine quilted âin-the-ditch.â The back has a sleeve for hanging. (Source: Suture for a Living)
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CD44 is critical for airway accumulation of antigenâspecific Th2 cells, but not Th1 cells, induced by antigen challenge in mice
In this study, we investigated the role of CD44 expressed on CD4+ T cells in the accumulation of T helper type 2 (Th2) cells in the airway using CD44âdeficient mice and antiâCD44 monoclonal antibodies. Antigenâinduced Th2âmediated airway inflammation and airway hyperresponsiveness (AHR) in sensitized mice were reduced by CD44âdeficency. These asthmatic responses induced by the transfer of antigenâsensitized splenic CD4+ T cells from CD44âdeficient mice were weaker than those from wildâtype mice. Lack of CD44 failed to induce AHR by antigen challenge. Expression level and hyaluronic acid receptor activity of CD44, as well as Neu1 sialidase expression on antigenâspecific Th2 cells were higher than those on antigenâspecific Th1 cells. AntiâCD44 antibody preferentially su...
F�r eine falten mit m�ssen die optimalen k�rperlichen Voraussetzungen, eine m�glichst stabile Gesundheit und Psyche der zu behandelnden Personen vorhanden sein.